Stress reduction shows: Results possible, but avoid these mistakes

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Tricyclic antidepressants such as Prozac and Zoloft and antidepressants in general (for example, fluoxetine, paroxetine, imipramine, mirtazapine) are widely prescribed to treat stress, as well as depression, anxiety, OCD, anxiety, PTSD, and other psychological conditions. It is often recommended that the patient avoid all psychotropic drugs such as SSRIs (selective serotonin reuptake inhibitors), SSRIs plus tricyclic antidepressants, and SSRIs plus SNRIs. (There are no studies showing that any of these medications is as effective as placebo as the placebo, and I have a great deal of experience with SSRIs and SNRIs.) The reason for these drugs' widespread use is that they have relatively low side effects, but high costs, and they are often prescribed as first-line drugs for patients with major depression, as well as anxiety and other psychological problems, or for short-term anxiety. (Tricyclic antidepressants may be considered more "first-line" than others, because they are used to treat the majority of depression patients. However, the risk of side effects with these drugs is much higher than with the other medications that can be used first-line to treat the same disorders.) Tricyclic antidepressants also help to reduce symptoms of anxiety and other mental disorders (in particular, OCD and posttraumatic stress disorder), but the side effects are also greater.

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